Medical genetics: advances in brief: Investigation of inheritance of chronic inflammatory bowel disease by complex segregation analysis
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چکیده
منابع مشابه
Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis.
OBJECTIVE To investigate the mode of inheritance of ulcerative colitis and Crohn's disease by complex segregation analysis. DESIGN Cross sectional population based survey of familial occurrence of chronic inflammatory bowel disease. SETTING Population of the Copenhagen county in 1987. SUBJECTS 662 patients in whom inflammatory bowel disease had been diagnosed before 1979, of whom 637 (96%...
متن کاملGenetics of inflammatory bowel disease.
1. The aetiology of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided little insight into disease pathogenesis. 2. Concordance rates in twin pairs and siblings provide strong evidence that genetic factors are important in disease pathogenesis. In Oxford, information was ob...
متن کاملInflammatory bowel disease: recent advances on genetics and innate immunity
The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. Insight into IBD is advancing rapidly owing to a plethora of investigations into intestinal inflammation in animal models, advances in the interrogation of diseases inherited as complex genetic traits, and the development o...
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The rapid pace of progress in molecular genetics over the past 15 years--since the seminal description of the polymerase chain reaction--has led to the identification of the genes involved in many single gene disorders. These successes in the laboratory have already led directly to clinical applications in diagnosis, pharmacogenetics, and the development of new therapies. Progress in unravellin...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1993
ISSN: 1468-6244
DOI: 10.1136/jmg.30.5.444-c